Can you take Melatonin with Zoloft?

It is not recommended to take Melatonin with Zoloft (sertraline). There is no evidence that there is an interaction between the two – but that is because taking melatonin and Zoloft together is largely untested. For safety, it is not recommended that you take Melatonin with Zoloft.

If you are unsure, you should speak to your doctor or a medical professional before using them both together.

If you want to know more about natural sleep aids, check out our Performance Lab Sleep review.

Why would you take Melatonin with Zoloft?

You may take Melatonin with Zoloft if you’re currently experiencing sleep problems alongside depression.

People who take Melatonin are usually using it to treat the following conditions:

  • Insomnia – Inability to get good quality sleep.
  • Jet Lag – Irregular sleep pattern from changing time zone.

Whereas those taking Zoloft may use it to treat:

  • Depression
  • Major Depressive Disorder
  • Obsessive Compulsive Disorder
  • Panic Disorder
  • Post Traumatic Stress Disorder
  • Postpartum Depression
  • Premenstrual Dysphoric Disorder
  • Social Anxiety Disorder

It is not uncommon for someone suffering from one of these mood-related conditions to also have trouble sleeping. So the leap to taking Melatonin on top of this medication is definitely a possibility.

Zoloft and Melatonin

Our concerns with taking Zoloft and Melatonin together

Although both can be useful to treat their respective problems, we believe that taking Zoloft and Melatonin together may cause problems – as there is little recorded evidence of what happens when the two are taken together.

Our main reasoning is that they are both potent and powerful drugs.

That and it’s also highly advised against taking Zoloft with alcohol. Alcohol can cause dizziness, drowsiness and difficulty concentration – which can amplify the drowsiness and dizziness you experience with Zoloft.

Melatonin’s main function is to cause drowsiness. Combined with Zoloft, it may be to much of a negative effect on your nervous system and may cause some discomfort and instability.

As we’ve said, there’s not a lot of evidence for the effects of Zoloft and Melatonin taken together – we can only speculate by how they both work independently.

If you want to get better insight, you should definitely speak to your doctor or a medical profession before taking the two together.

Risks from taking Zoloft

When taking Zoloft you should be aware that is been known to cause the following side effects:

  • Sleepiness
  • Drowsiness
  • General Fatigue
  • Nervousness
  • Sleep Problems (insomnia)
  • Dizziness
  • Nausea
  • Skin Rash
  • Headache
  • Diarrhea
  • Constipation
  • Upset Stomach
  • Stomach Pain
  • Dry Mouth
  • Changes in Appetite
  • Abnormal Ejaculation
  • Impotence
  • Decreased Sex Drive
  • Difficulty having an Orgasm
  • Dry Mouth
  • Weight Loss

As always, you should always have a prescription for taking Zoloft from a doctor / qualified medical professional. This is not something to be self-medicating with.

The main ones to note here related to Melatonin are the sleepiness, drowsiness and fatigue. Combined with those effects you’re already getting from Melatonin, you may get more than you bargained for.

Risks from taking Melatonin

Taking pure Melatonin straight may cause side effects, especially if you’re taking a high dosage.

Potential (although unlikely) side effects from Melatonin include:

  • Headache
  • Dizziness
  • Nausea
  • Drowsiness

Again, the drowsiness is expected as this is the main purpose of supplementing Melatonin but with Zoloft having the risk of causing this too – it could exacerbate problems.

We highly advise anyone who is thinking of taking Melatonin and Zoloft together should speak to their doctor before doing so.


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