Can you take melatonin with Nyquil?

It is not recommended to take Melatonin and Nyquil together. There are no studies into this choice specifically, however, taking both could lead to side effects such as sleep-related disturbances, central nervous system and respiratory depression.

If any of these (or any other) side effects occur while using Nyquil with Melatonin you should stop combining them immediately and only choose one for future usage.

You should absolutely talk to your doctor or a medical professional before combining melatonin with Nyquil.

To see our top natural sleep aid, check out our Performance Lab Sleep review.

Potential Side Effects of Taking Melatonin with Nyquil

Potential side effects of Melatoin and Nyquil include:

  • Additive Sedation
  • Sleep-related Disturbances
  • Central Nervous System Depression
  • Respiratory Depression

This is what may happen when you take Nyquil and Melatonin together.

Nyquil typically contains the following ingredients:

  • Acetaminophen
  • Dextromethorphan
  • Doxylamine

These could pose a problem to something like Melatonin. But first let’s look at what these Nyquil ingredients do and why.

Acetaminophen is a painkiller which can help make you more relaxed, whereas dextromethorphan is a cough suppressant, finally doxylamine is antihistamine, allergy medication which can help prevent sinus problems.

They basically put you in a good enough condition to comfortably fall asleep.

The problem is when you introduce Melatonin into the mix. Melatonin can sedate you and have depressant effects on your central nervous system. Doxylamine also does this – and using them together may have too much of a sedation effect and cause problems.

Melatonin and Nyquil Side Effects

How Nyquil Works

Nyquil’s ingredients fall under the category of antihistamines. The main ingredient used in products like Nyquil is usually doxylamine, which is an antihistamine.  Doxylamine is linked to causing drowsiness because it doesn’t target any particular tissue when it is fighting the histamine response which can make you sleepier.

The problem is that your body can build up a tolerance to the sedating effects of doxylamine. You should not rely on it to promote drowsiness – as you will need more and more to get the full effects from this over-the-counter sleep aid. This can lead to serious problems if you plan on upping the dosage – especially if you’re adding Melatonin to it.

How Melatonin Works

Melatonin is a natural hormone in your body that is made in your pineal gland and regulates your sleep. It is responsible for sleep cycle and your circadian rhythm.

It is the hormone that signals to your body that it is time to go to sleep.

Melatonin is typically used in supplements to promote sleep. The only problem is that some of the supplements use synthetic melatonin which isn’t always as effective as it is harder to absorb and that it doesn’t come from natural sources.

However, when it does work, it can send a message to your body that it is time for you to go to sleep.


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